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Cytotoxicity and cellular uptake evaluation of mitoxantrone-loaded poly(lactic acid-co-lysine) arginine-glycine-aspartic acid nanoparticles

This study was undertaken to evaluate the in vitro characteristics of poly(lactic acid-co-lysine) arginine-glycine-aspartic acid (PLA-PLL-RGD) nanoparticles (NPs) loaded with mitoxantrone; the association processes of NPs with MCF-7 cells, including binding and effective internalization, were investigated in vitro. Journal of Applied Polymer Science, 119(2): 1011-1015 (January 2011) International Council on Nanotechnology, Rice University – Virtual [...]

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Mineralization of Monodispersed CdS Nanoparticles on Polyelectrolyte Superstructure Forming an Electroluminescent “Necklace-of-Beads”

We report a nonmicellar method to synthesize monodisperse semiconducting nanoparticles templated on polymer chains dissolved in solution at high yield. The monodispersity is achieved due to the beaded necklace morphology of the polyelectrolyte chains in solution where the beads are nanometer-scale nodules in the polymer chain. The resultant structure is a nanoparticles studded necklace where [...]

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Self-Assembling Gold Nanoparticles Use Light to Kill Tumor Cells

When irradiated with light, gold nanoparticles become hot quickly, hot enough to generate explosive microbubbles that will kill nearby cancer cells, a physical process known as the photothermal effect. To boost this approach, researchers at the University of California, Los Angeles, have developed a method for creating supramolecular assemblies of gold nanoparticles that function as [...]

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Self-Assembly of Nanoparticles on Live Bacterium: An Avenue to Fabricate Electronic Devices

Recently, hybrid structures of microorganisms with inorganic nanoscale moieties have received great interest owing to their potential in fabricating electronic systems. The electronic properties of metal nanoparticles, as a result of the singleelectron transport of current,[1] make them ideal materials for nanodevices. Concomitantly, the nanostructure of microorganisms such as bacteria,[2] viruses,[3, 4] and yeast[5] are [...]

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Optimized Method for Preparation of TiO2 Nanoparticles Dispersion for Biological Study

The objective of this study was to develop a practical method to prepare a stable dispersion of TiO2 nanoparticles for biological studies. TiO2 (rutile/anatase) dispersions were prepared in distilled water following by treated with different ultrasound energies and various dispersion stabilizers.Journal of Nanoscience and Nanotechnology, 10(8): 5213-5219 (August 2010) International Council on Nanotechnology, Rice University [...]

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